A KCNK16 mutation causing TALK-1 gain of function is associated with maturity-onset diabetes of the young

Maturity-onset diabetes of the young (MODY) is a heterogeneous group of monogenic disorders of impaired pancreatic β cell function. The mechanisms underlying MODY include β cell KATP channel dysfunction (e.g., KCNJ11 [MODY13] or ABCC8 [MODY12] mutations); however, no other β cell channelopathies hav...

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Κύριοι συγγραφείς:	Sarah M. Graff, Stephanie R. Johnson, Paul J. Leo, Prasanna K. Dadi, Matthew T. Dickerson, Arya Y. Nakhe, Aideen M. McInerney-Leo, Mhairi Marshall, Karolina E. Zaborska, Charles M. Schaub, Matthew A. Brown, David A. Jacobson, Emma L. Duncan
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	American Society for Clinical investigation 2021-07-01
Σειρά:	JCI Insight
Θέματα:	Endocrinology Genetics
Διαθέσιμο Online:	https://doi.org/10.1172/jci.insight.138057
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