SREBP-1 upregulates lipophagy to maintain cholesterol homeostasis in brain tumor cells

Summary: Cholesterol is a structural component of cell membranes. How rapidly growing tumor cells maintain membrane cholesterol homeostasis is poorly understood. Here, we found that glioblastoma (GBM), the most lethal brain tumor, maintains normal levels of membrane cholesterol but with an abundant...

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Detalhes bibliográficos

Principais autores:	Feng Geng, Yaogang Zhong, Huali Su, Etienne Lefai, Shino Magaki, Timothy F. Cloughesy, William H. Yong, Arnab Chakravarti, Deliang Guo
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2023-07-01
coleção:	Cell Reports
Assuntos:	CP: Metabolism CP: Cancer
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S221112472300801X
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