Constraint-based modeling of bioenergetic differences between synaptic and non-synaptic components of dopaminergic neurons in Parkinson’s disease

IntroductionEmerging evidence suggests that different metabolic characteristics, particularly bioenergetic differences, between the synaptic terminal and soma may contribute to the selective vulnerability of dopaminergic neurons in patients with Parkinson’s disease (PD).MethodTo investigate the meta...

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Autors principals:	Xi Luo, Diana C. El Assal, Yanjun Liu, Samira Ranjbar, Ronan M.T. Fleming
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2025-06-01
Col·lecció:	Frontiers in Computational Neuroscience
Matèries:	Parkinson’s disease bioenergetics synaptic non-synaptic modeling
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fncom.2025.1594330/full
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