Constraint-based modeling of bioenergetic differences between synaptic and non-synaptic components of dopaminergic neurons in Parkinson’s disease

IntroductionEmerging evidence suggests that different metabolic characteristics, particularly bioenergetic differences, between the synaptic terminal and soma may contribute to the selective vulnerability of dopaminergic neurons in patients with Parkinson’s disease (PD).MethodTo investigate the meta...

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Ngā kaituhi matua:	Xi Luo, Diana C. El Assal, Yanjun Liu, Samira Ranjbar, Ronan M.T. Fleming
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Frontiers Media S.A. 2025-06-01
Rangatū:	Frontiers in Computational Neuroscience
Ngā marau:	Parkinson’s disease bioenergetics synaptic non-synaptic modeling
Urunga tuihono:	https://www.frontiersin.org/articles/10.3389/fncom.2025.1594330/full
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