Whole genome analysis of CRISPR Cas9 sgRNA off-target homologies via an efficient computational algorithm
Abstract Background The beauty and power of the genome editing mechanism, CRISPR Cas9 endonuclease system, lies in the fact that it is RNA-programmable such that Cas9 can be guided to any genomic loci complementary to a 20-nt RNA, single guide RNA (sgRNA), to cleave double stranded DNA, allowing the...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
BMC
2017-11-01
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| シリーズ: | BMC Genomics |
| 主題: | |
| オンライン･アクセス: | http://link.springer.com/article/10.1186/s12864-017-4225-1 |
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