mTOR activation induces endolysosomal remodeling and nonclassical secretion of IL-32 via exosomes in inflammatory reactive astrocytes

Abstract Astrocytes respond and contribute to neuroinflammation by adopting inflammatory reactive states. Although recent efforts have characterized the gene expression signatures associated with these reactive states, the cell biology underlying inflammatory reactive astrocyte phenotypes remains un...

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Autori principali:	Kun Leng, Brendan Rooney, Frank McCarthy, Wenlong Xia, Indigo V. L. Rose, Sophie Bax, Marcus Chin, Saeed Fathi, Kari A. Herrington, Manuel Leonetti, Aimee Kao, Stephen P. J. Fancy, Joshua E. Elias, Martin Kampmann
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2024-08-01
Serie:	Journal of Neuroinflammation
Soggetti:	Astrocytes Inflammatory reactive astrocytes Neuroinflammation mTOR Endolysosomal system IL-32
Accesso online:	https://doi.org/10.1186/s12974-024-03165-w
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