mTOR activation induces endolysosomal remodeling and nonclassical secretion of IL-32 via exosomes in inflammatory reactive astrocytes

Abstract Astrocytes respond and contribute to neuroinflammation by adopting inflammatory reactive states. Although recent efforts have characterized the gene expression signatures associated with these reactive states, the cell biology underlying inflammatory reactive astrocyte phenotypes remains un...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Kun Leng, Brendan Rooney, Frank McCarthy, Wenlong Xia, Indigo V. L. Rose, Sophie Bax, Marcus Chin, Saeed Fathi, Kari A. Herrington, Manuel Leonetti, Aimee Kao, Stephen P. J. Fancy, Joshua E. Elias, Martin Kampmann
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	BMC 2024-08-01
Sarja:	Journal of Neuroinflammation
Aiheet:	Astrocytes Inflammatory reactive astrocytes Neuroinflammation mTOR Endolysosomal system IL-32
Linkit:	https://doi.org/10.1186/s12974-024-03165-w
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