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Immunoglobulin M regulates airway hyperresponsiveness independent of T helper 2 allergic inflammation

Allergic asthma is a disease driven by T helper 2 (Th2) cells, eosinophilia, airway hyperresponsiveness (AHR), and IgE-secreting B cells. Asthma is largely controlled by corticosteroids and β2 adrenergic receptor agonists that target and relax airway smooth muscle (ASM). Immunoglobulin M (IgM) isoty...

Whakaahuatanga katoa

I tiakina i:
Ngā kaituhi matua: Sabelo Hadebe, Anca Flavia Savulescu, Jermaine Khumalo, Katelyn Jones, Sandisiwe Mangali, Nontobeko Mthembu, Fungai Musaigwa, Welcome Maepa, Hlumani Ndlovu, Amkele Ngomti, Martyna Scibiorek, Javan Okendo, Frank Brombacher
Hōputu: Artigo
Reo:Inglês
I whakaputaina: eLife Sciences Publications Ltd 2025-12-01
Rangatū:eLife
Ngā marau:
Immunoglobulin M
B cells
airway hyperresponsiveness
airway smooth muscle
single cell force cytometry
fluorescently labelled elastomeric contractible surface
Urunga tuihono:https://elifesciences.org/articles/90531
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