Immunoglobulin M regulates airway hyperresponsiveness independent of T helper 2 allergic inflammation

Allergic asthma is a disease driven by T helper 2 (Th2) cells, eosinophilia, airway hyperresponsiveness (AHR), and IgE-secreting B cells. Asthma is largely controlled by corticosteroids and β2 adrenergic receptor agonists that target and relax airway smooth muscle (ASM). Immunoglobulin M (IgM) isoty...

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Bibliografiske detaljer

Principais autores:	Sabelo Hadebe, Anca Flavia Savulescu, Jermaine Khumalo, Katelyn Jones, Sandisiwe Mangali, Nontobeko Mthembu, Fungai Musaigwa, Welcome Maepa, Hlumani Ndlovu, Amkele Ngomti, Martyna Scibiorek, Javan Okendo, Frank Brombacher
Format:	Artigo
Sprog:	Inglês
Udgivet:	eLife Sciences Publications Ltd 2025-12-01
Serier:	eLife
Fag:	Immunoglobulin M B cells airway hyperresponsiveness airway smooth muscle single cell force cytometry fluorescently labelled elastomeric contractible surface
Online adgang:	https://elifesciences.org/articles/90531
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