Signature-based small molecule screening identifies cytosine arabinoside as an EWS/FLI modulator in Ewing sarcoma.
<h4>Background</h4>The presence of tumor-specific mutations in the cancer genome represents a potential opportunity for pharmacologic intervention to therapeutic benefit. Unfortunately, many classes of oncoproteins (e.g., transcription factors) are not amenable to conventional small-molecule screeni...
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| Автори: | , , , , , , , , |
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| Формат: | Artigo |
| Мова: | Inglês |
| Опубліковано: |
Public Library of Science (PLoS)
2007-04-01
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| Серія: | PLoS Medicine |
| Онлайн доступ: | https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.0040122&type=printable |
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