Signature-based small molecule screening identifies cytosine arabinoside as an EWS/FLI modulator in Ewing sarcoma.

<h4>Background</h4>The presence of tumor-specific mutations in the cancer genome represents a potential opportunity for pharmacologic intervention to therapeutic benefit. Unfortunately, many classes of oncoproteins (e.g., transcription factors) are not amenable to conventional small-molecule screeni...

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Bibliografski detalji

Glavni autori:	Kimberly Stegmaier, Jenny S Wong, Kenneth N Ross, Kwan T Chow, David Peck, Renee D Wright, Stephen L Lessnick, Andrew L Kung, Todd R Golub
Format:	Artigo
Jezik:	Inglês
Izdano:	Public Library of Science (PLoS) 2007-04-01
Serija:	PLoS Medicine
Online pristup:	https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.0040122&type=printable
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