Functional Analysis of Cancer-Associated DNA Polymerase ε Variants in Saccharomyces cerevisiae
DNA replication fidelity relies on base selectivity of the replicative DNA polymerases, exonucleolytic proofreading, and postreplicative DNA mismatch repair (MMR). Ultramutated human cancers without MMR defects carry alterations in the exonuclease domain of DNA polymerase ε (Polε). They have been hy...
שמור ב:
| Principais autores: | , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Oxford University Press
2018-03-01
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| סדרה: | G3: Genes, Genomes, Genetics |
| נושאים: | |
| גישה מקוונת: | http://g3journal.org/lookup/doi/10.1534/g3.118.200042 |
| תגים: |
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