Functional Analysis of Cancer-Associated DNA Polymerase ε Variants in Saccharomyces cerevisiae
DNA replication fidelity relies on base selectivity of the replicative DNA polymerases, exonucleolytic proofreading, and postreplicative DNA mismatch repair (MMR). Ultramutated human cancers without MMR defects carry alterations in the exonuclease domain of DNA polymerase ε (Polε). They have been hy...
में बचाया:
| मुख्य लेखकों: | , , , |
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| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
Oxford University Press
2018-03-01
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| श्रृंखला: | G3: Genes, Genomes, Genetics |
| विषय: | |
| ऑनलाइन पहुंच: | http://g3journal.org/lookup/doi/10.1534/g3.118.200042 |
| टैग: |
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