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The SDF-1α/CXCR4 axis regulates chondrocyte mitochondrial dynamics via the ERK/AMPKα pathway

Abstract Mitochondrial quality control is crucial for maintaining chondrocyte homeostasis, and mitochondrial dysfunction is a key contributor to osteoarthritic (OA) pathogenesis. Reports have indicated that the level of SDF-1α increases during the progression of OA; however, its effects on mitochond...

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Principais autores: Jiazhou Li, Hao Chen, Mengmeng Duan, Sijun Liu, Shasha Tu, Li Zhang, Xuedong Zhou, Jing Xie
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2026-03-01
Series:Cell Communication and Signaling
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Acceso en liña:https://doi.org/10.1186/s12964-026-02827-x
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