Spatial lipidomics reveals demyelination and remyelination dynamics in the mouse brain

Myelin pathology in demyelinating diseases is accompanied by lipid remodeling that remains challenging to characterize at the spatial level using traditional mass spectrometry. We developed an optimized AP-MALDI-Orbitrap MSI pipeline, incorporating sample preparation improvements and mass recalibrat...

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Autors principals:	Mikolaj Opielka, Krzysztof Urbanowicz, Klaudia Konieczna-Wolska, Elisabeth Müller, Oliwier Krajewski, Maureen Feucherolles, Qiuqin Zhou, Michal Bienkowski, Gilles Frache, Carsten Hopf, Lucas Schirmer, Aleksandra Rutkowska, Ryszard T. Smolenski
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2025-11-01
Col·lecció:	Journal of Lipid Research
Matèries:	AP-MALDI-MSI mass spectrometry imaging 4D-LC-TIMS-MS cuprizone model demyelination remyelination
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S0022227525001749
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