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Spatial lipidomics reveals demyelination and remyelination dynamics in the mouse brain

Myelin pathology in demyelinating diseases is accompanied by lipid remodeling that remains challenging to characterize at the spatial level using traditional mass spectrometry. We developed an optimized AP-MALDI-Orbitrap MSI pipeline, incorporating sample preparation improvements and mass recalibrat...

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Furkejuvvon:
Váldodahkkit: Mikolaj Opielka, Krzysztof Urbanowicz, Klaudia Konieczna-Wolska, Elisabeth Müller, Oliwier Krajewski, Maureen Feucherolles, Qiuqin Zhou, Michal Bienkowski, Gilles Frache, Carsten Hopf, Lucas Schirmer, Aleksandra Rutkowska, Ryszard T. Smolenski
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: Elsevier 2025-11-01
Ráidu:Journal of Lipid Research
Fáttát:
AP-MALDI-MSI
mass spectrometry imaging
4D-LC-TIMS-MS
cuprizone model
demyelination
remyelination
Liŋkkat:http://www.sciencedirect.com/science/article/pii/S0022227525001749
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