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Proof-of-Principle Study of Inflammasome Signaling Proteins as Diagnostic Biomarkers of the Inflammatory Response in Parkinson’s Disease

Parkinson’s disease (PD) is a neurodegenerative disorder marked by the death of dopaminergic neurons in the midbrain, the accumulation of α-synuclein aggregates, and motor deficits. A major contributor to dopaminergic neuronal loss is neuroinflammation. The inflammasome is a multiprotein complex tha...

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Main Authors: Erika d. l. R. M. Cabrera Ranaldi, Karen Nuytemans, Anisley Martinez, Corneliu C. Luca, Robert W. Keane, Juan Pablo de Rivero Vaccari
Format: Artigo
Language:Inglês
Published: MDPI AG 2023-06-01
Series:Pharmaceuticals
Subjects:
inflammasome
biomarkers
caspase-1
ASC
Parkinson’s disease
Online Access:https://www.mdpi.com/1424-8247/16/6/883
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