Phenome-wide association of APOE alleles in the All of Us Research ProgramResearch in context

Summary: Background: Apolipoprotein E (APOE) variation is associated with altered lipid metabolism, as well as cardiovascular and neurodegenerative disease. Prior studies are largely limited to European ancestry populations and differential risk by sex and ancestry has not been widely evaluated. Me...

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Autori principali:	Ehsan Khajouei, Valentina Ghisays, Ignazio S. Piras, Kiana L. Martinez, Anthony T. Vicenti, Marcus Naymik, Preston Ngo, Tam C. Tran, Joshua C. Denny, Travis J. Wheeler, Matthew J. Huentelman, Eric M. Reiman, Jason H. Karnes
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2025-07-01
Serie:	EBioMedicine
Soggetti:	Apolipoprotein E Phenome-wide association study Health disparities Alzheimer’s disease Hypercholesterolaemia
Accesso online:	http://www.sciencedirect.com/science/article/pii/S2352396425002129
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