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Enhanced response rate to pegylated liposomal doxorubicin in high grade serous ovarian carcinomas harbouring BRCA1 and BRCA2 aberrations

Abstract Background Approximately 10–15% of ovarian carcinomas (OC) are attributed to inherited susceptibility, the majority of which are due to mutations in BRCA1 or BRCA2 (BRCA1/2). These patients display superior clinical outcome, including enhanced sensitivity to platinum-based chemotherapy. Her...

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Main Authors: Robert L. Hollis, Alison M. Meynert, Michael Churchman, Tzyvia Rye, Melanie Mackean, Fiona Nussey, Mark J. Arends, Andrew H. Sims, Colin A. Semple, C. Simon Herrington, Charlie Gourley
Format: Artigo
Language:Inglês
Published: BMC 2018-01-01
Series:BMC Cancer
Subjects:
Ovarian cancer
BRCA1
BRCA2
PLDH
Online Access:http://link.springer.com/article/10.1186/s12885-017-3981-2
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