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Enhancing Oral Absorption of an Ester Prodrug by Coating Drug Crystals with Binary Lipid Systems and Evaluating the Influence of Compositions

<b>Background/Objectives</b>: Prodrug strategies are a vital aspect of drug development, with ester prodrugs particularly notable for modifying parent drug properties through ester functional groups to enhance oral absorption. However, ester prodrugs are prone to hydrolysis by water and enzymes, mak...

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Principais autores: Xiaowei Dong, Tao Zhang, Hellen L. Moreno Sanchez, Jaylen C. Mans, Sung Hun Bae, Liangqiao Bian
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2025-09-01
coleção:Pharmaceutics
Assuntos:
ester prodrugs
degradation
stability
olmesartan medoxomil
oral absorption enhancement
Acesso em linha:https://www.mdpi.com/1999-4923/17/9/1210
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