CHCHD4 regulates tumour proliferation and EMT-related phenotypes, through respiratory chain-mediated metabolism

Abstract Background Mitochondrial oxidative phosphorylation (OXPHOS) via the respiratory chain is required for the maintenance of tumour cell proliferation and regulation of epithelial to mesenchymal transition (EMT)-related phenotypes through mechanisms that are not fully understood. The essential...

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Detalhes bibliográficos

Principais autores:	Luke W. Thomas, Cinzia Esposito, Jenna M. Stephen, Ana S. H. Costa, Christian Frezza, Thomas S. Blacker, Gyorgy Szabadkai, Margaret Ashcroft
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2019-07-01
coleção:	Cancer & Metabolism
Assuntos:	Coiled-coil helix coiled-coil helix domain-containing protein 4 (CHCHD4) hypoxia HIF-1α mitochondria respiratory chain disulfide relay system
Acesso em linha:	http://link.springer.com/article/10.1186/s40170-019-0200-4
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