Structural insights and clinical advances in small-molecule inhibitors targeting TGF-β receptor I

The dysregulation of the transforming growth factor β (TGF-β) signaling pathway plays a critical role in the onset and progression of several diseases, including cancer. Notably, TGF-β has emerged as a significant barrier to effective outcomes in cancer immunotherapies, particularly those using immu...

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Principais autores:	Carlota Leonardo-Sousa, Rodrigo Barriga, Helena F. Florindo, Rita C. Acúrcio, Rita C. Guedes
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Elsevier 2025-03-01
סדרה:	Molecular Therapy: Oncology
נושאים:	MT: Regular Issue transforming growth factor β TGF-β TGF-β receptor I TGF-βRI TGF-βRI inhibitors
גישה מקוונת:	http://www.sciencedirect.com/science/article/pii/S2950329925000141
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