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Fenofibrate inhibits TGF‐β‐induced myofibroblast differentiation and activation in human lung fibroblasts in vitro

Fenofibrate (FF), a peroxisome proliferator‐activated receptor‐alpha (PPAR‐α) agonist and a lipid‐lowering agent, can decrease experimental pulmonary fibrosis. However, the mechanisms underlying the antifibrotic effect of FF remain unknown. Hence, this study was conducted to evaluate the effects of...

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Principais autores: Ryota Kikuchi, Yuki Maeda, Takao Tsuji, Kazuhiro Yamaguchi, Shinji Abe, Hiroyuki Nakamura, Kazutetsu Aoshiba
Formato: Artigo
Idioma:Inglês
Publicado: Wiley 2021-08-01
Series:FEBS Open Bio
Assuntos:
fenofibrate
myofibroblasts
PPARα
pulmonary fibrosis
TGF‐β
Acceso en liña:https://doi.org/10.1002/2211-5463.13247
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