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Axonal distribution of mitochondria maintains neuronal autophagy during aging via eIF2β

Neuronal aging and neurodegenerative diseases are accompanied by proteostasis collapse, while the cellular factors that trigger it have not been identified. Impaired mitochondrial transport in the axon is another feature of aging and neurodegenerative diseases. Using Drosophila, we found that geneti...

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Principais autores: Kanako Shinno, Yuri Miura, Koichi M Iijima, Emiko Suzuki, Kanae Ando
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications Ltd 2026-01-01
Serier:eLife
Fag:
mitochondria
aging
proteome
neuronal proteostasis
protein aggregation
autophagy
Online adgang:https://elifesciences.org/articles/95576
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