The ubiquitin ligase UBR5 suppresses proteostasis collapse in pluripotent stem cells from Huntington’s disease patients

Induced pluripotent stem cells (iPSCs) suppress the aggregation of Huntington’s disease (HD) polyQ-expanded huntingtin (HTT). Here the authors show that proteasome activity determines the levels of mutant HTT in HD-iPSCs and find that UBR5 is a modulator of super-vigilant proteostasis of iPSCs.

Xehetasun bibliografikoak

Egile Nagusiak:	Seda Koyuncu, Isabel Saez, Hyun Ju Lee, Ricardo Gutierrez-Garcia, Wojciech Pokrzywa, Azra Fatima, Thorsten Hoppe, David Vilchez
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Nature Portfolio 2018-07-01
Saila:	Nature Communications
Sarrera elektronikoa:	https://doi.org/10.1038/s41467-018-05320-3
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