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Coordinated ARP2/3 and glycolytic activities regulate the morphological and functional fitness of human CD8+ T cells

Summary: Actin cytoskeleton remodeling sustains the ability of cytotoxic T cells to search for target cells and eliminate them. We here investigated the relationship between energetic status, actin remodeling, and functional fitness in human CD8+ effector T cells. Cell spreading during migration or...

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Principais autores: Anton Kamnev, Tanvi Mehta, Matthias Wielscher, Beatriz Chaves, Claire Lacouture, Anna-Katharina Mautner, Lisa E. Shaw, Michael Caldera, Jörg Menche, Wolfgang P. Weninger, Matthias Farlik, Kaan Boztug, Loïc Dupré
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2024-03-01
Serier:Cell Reports
Fag:
CP: Immunology
CP: Cell biology
Online adgang:http://www.sciencedirect.com/science/article/pii/S2211124724001815
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