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Multi-omics after O-GlcNAc alteration identified cellular processes promoting aneuploidy after loss of O-GlcNAc transferase

Objective: Pharmacologic or genetic manipulation of O-GlcNAcylation, an intracellular, single sugar post-translational modification, are difficult to interpret due to the pleotropic nature of O-GlcNAc and the vast signaling pathways it regulates. Method: To address the pleotropic nature of O-GlcNAc,...

Whakaahuatanga katoa

I tiakina i:
Ngā kaituhi matua: Samuel S. Boyd, Dakota R. Robarts, Khue Nguyen, Maite Villar, Ibtihal M. Alghusen, Manasi Kotulkar, Aspin Denson, Halyna Fedosyuk, Stephen A. Whelan, Norman C.Y. Lee, John Hanover, Wagner B. Dias, Ee Phie Tan, Steven R. McGreal, Antonio Artigues, Russell H. Swerdlow, Jeffrey A. Thompson, Udayan Apte, Chad Slawson
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Elsevier 2024-12-01
Rangatū:Molecular Metabolism
Ngā marau:
O-GlcNAc
OGT
OGA
Cell cycle
Aneuploidy
mTOR
Urunga tuihono:http://www.sciencedirect.com/science/article/pii/S2212877824001911
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