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O-GlcNAc regulates the mitochondrial integrated stress response by regulating ATF4

BackgroundAccumulation of mitochondrial dysfunctional is a hallmark of age-related neurodegeneration including Alzheimer’s disease (AD). Impairment of mitochondrial quality control mechanisms leading to the accumulation of damaged mitochondria and increasing neuronal stress. Therefore, investigating...

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Bibliografische Detailangaben
Hauptverfasser: Ibtihal M. Alghusen, Marisa S. Carman, Heather Wilkins, Sophiya John Ephrame, Amy Qiang, Wagner B. Dias, Halyna Fedosyuk, Aspin R. Denson, Russell H. Swerdlow, Chad Slawson
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2023-12-01
Schriftenreihe:Frontiers in Aging Neuroscience
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Online-Zugang:https://www.frontiersin.org/articles/10.3389/fnagi.2023.1326127/full
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