The regulatory subunit of PKA-I remains partially structured and undergoes β-aggregation upon thermal denaturation.

<h4>Background</h4>The regulatory subunit (R) of cAMP-dependent protein kinase (PKA) is a modular flexible protein that responds with large conformational changes to the binding of the effector cAMP. Considering its highly dynamic nature, the protein is rather stable. We studied the thermal denatura...

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Detalles Bibliográficos

Principais autores:	Khanh K Dao, Angel L Pey, Anja Underhaug Gjerde, Knut Teigen, In-Ja L Byeon, Stein O Døskeland, Angela M Gronenborn, Aurora Martinez
Formato:	Artigo
Idioma:	Inglês
Publicado:	Public Library of Science (PLoS) 2011-03-01
Series:	PLoS ONE
Acceso en liña:	https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21394209/pdf/?tool=EBI
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