Development of novel lipoplex formulation methodologies to improve large-scale transient transfection for lentiviral vector manufacture

Large-scale transient transfection has advanced significantly over the last 20 years, enabling the effective production of a diverse range of biopharmaceutical products, including viral vectors. However, a number of challenges specifically related to transfection reagent stability and transfection c...

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Detalhes bibliográficos

Principais autores:	Thomas Williams-Fegredo, Lee Davies, Carol Knevelman, Kyriacos Mitrophanous, James Miskin, Qasim A. Rafiq
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2024-06-01
coleção:	Molecular Therapy: Methods & Clinical Development
Assuntos:	lentiviral vector transient transfection transient gene expression HEK293T cationic liposomes lipoplexes
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2329050124000767
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