Copper delivery to the CNS by CuATSM effectively treats motor neuron disease in SODG93A mice co-expressing the Copper-Chaperone-for-SOD

Over-expression of mutant copper, zinc superoxide dismutase (SOD) in mice induces ALS and has become the most widely used model of neurodegeneration. However, no pharmaceutical agent in 20 years has extended lifespan by more than a few weeks. The Copper-Chaperone-for-SOD (CCS) protein completes the...

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Detalhes bibliográficos

Principais autores:	Jared R. Williams, Emiliano Trias, Pamela R. Beilby, Nathan I. Lopez, Edwin M. Labut, C. Samuel Bradford, Blaine R. Roberts, Erin J. McAllum, Peter J. Crouch, Timothy W. Rhoads, Cliff Pereira, Marjatta Son, Jeffrey L. Elliott, Maria Clara Franco, Alvaro G. Estévez, Luis Barbeito, Joseph S. Beckman
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2016-05-01
coleção:	Neurobiology of Disease
Assuntos:	SOD1 Lou Gehrig Amyotrophic lateral sclerosis Superoxide dismutase CCS
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S0969996116300201
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