Aberrant intra‐epithelial lymphocytes cause enterocyte cell death in refractory celiac disease by CD103‐β7‐receptor‐mediated granzyme‐B degranulation which can be restored by etrolizumab

Abstract Objectives Refractory celiac disease type II (RCDII) is an intestinal tumor of aberrant intra‐epithelial T‐lymphocytes (IEL). The severe enteropathy found in RCDII is caused by aberrant IEL that exert cytotoxicity against enterocytes. In this study, we investigated the cell death mechanism...

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Ngā kaituhi matua:	Daan A R Castelijn, Jolanda M W van deWater, Laura R deBaaij, Bridget S McGlinchy, Michelle vanLeeuwen, Sander P J Joosten, Nikita Alberts, Margherita Rossi, Martine Reijm, Jolien C Hollander, Petra Bonnet, Yvonne M C Kooy‐Winkelaar, Frits Koning, Steven T Pals, Gerd Bouma, Chris J L M Meijer, Hetty J Bontkes, Chris J J Mulder, Saskia A G M Cillessen
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Wiley 2026-05-01
Rangatū:	Clinical & Translational Immunology
Ngā marau:	autoimmunity cell death enteropathy intestinal inflammation
Urunga tuihono:	https://doi.org/10.1002/cti2.70099
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!