Aberrant intra‐epithelial lymphocytes cause enterocyte cell death in refractory celiac disease by CD103‐β7‐receptor‐mediated granzyme‐B degranulation which can be restored by etrolizumab

Abstract Objectives Refractory celiac disease type II (RCDII) is an intestinal tumor of aberrant intra‐epithelial T‐lymphocytes (IEL). The severe enteropathy found in RCDII is caused by aberrant IEL that exert cytotoxicity against enterocytes. In this study, we investigated the cell death mechanism...

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Auteurs principaux:	Daan A R Castelijn, Jolanda M W van deWater, Laura R deBaaij, Bridget S McGlinchy, Michelle vanLeeuwen, Sander P J Joosten, Nikita Alberts, Margherita Rossi, Martine Reijm, Jolien C Hollander, Petra Bonnet, Yvonne M C Kooy‐Winkelaar, Frits Koning, Steven T Pals, Gerd Bouma, Chris J L M Meijer, Hetty J Bontkes, Chris J J Mulder, Saskia A G M Cillessen
Format:	Artigo
Langue:	Inglês
Publié:	Wiley 2026-05-01
Collection:	Clinical & Translational Immunology
Sujets:	autoimmunity cell death enteropathy intestinal inflammation
Accès en ligne:	https://doi.org/10.1002/cti2.70099
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