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Selective cyclooxygenase-2 inhibitor celecoxib could sensitize B-cell-originated lymphoma cell lines to epirubicin via down-regulation of MDR-1 mRNA and Bcl-2 mRNA expression

Background and purpose: It has been demonstrated that cyclooxygenase-2 (COX-2) is overexpressed in some subtypes of non-Hodgkin’s lymphoma (NHL), and COX-2 correlates with the expression of P-glycoprotein and Bcl-2, which may contribute to chemotherapy-resistance in NHL. The purpose of this study wa...

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Principais autores: 化范例, 王玲燕, 赵鑫
פורמט: Artigo
שפה:Inglês
יצא לאור: Editorial Office of China Oncology 2015-08-01
סדרה:Zhongguo aizheng zazhi
נושאים:
Cyclooxygenase-2
Celecoxib
Lymphoma
MDR-1 gene
<em>Bcl-2</em>gene
גישה מקוונת:http://www.china-oncology.com/thesisDetails#10.3969/j.issn.1007-3969.2015.06.005
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