Using 6S-5-methyltetrahydrofolate instead of folic acid in prenatal multivitamin reduces unmetabolized folic acid concentrations in the mother-fetus dyad: a 24-week randomized controlled trial

A growing number of prenatal multivitamin (MVI) products use 5-methyltetrahydrofolate (5-MTHF) in place of the synthetic folic acid (FA), because FA needs to be reduced to 5-MTHF for use in cellular methylation reactions and excess FA consumption can increase unmetabolized FA (UMFA) concentrations i...

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मुख्य लेखकों:	Fulvia Draicchio, Jeanette Hausser, Mastaneh Sharafi, Adeline Grier-Welch, Arianne Vance, Nima Alamdari, Itamar D. Futterman, Scott Chudnoff, Olga Malysheva, Marie A. Caudill, Isabelle Hanson, Xinyin Jiang
स्वरूप:	Artigo
भाषा:	Inglês
प्रकाशित:	Frontiers Media S.A. 2026-03-01
श्रृंखला:	Frontiers in Nutrition
विषय:	5-methyltetrahydrofolate folic acid pregnancy prenatal multivitamin unmetabolized folic acid
ऑनलाइन पहुंच:	https://www.frontiersin.org/articles/10.3389/fnut.2026.1679067/full
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