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Using 6S-5-methyltetrahydrofolate instead of folic acid in prenatal multivitamin reduces unmetabolized folic acid concentrations in the mother-fetus dyad: a 24-week randomized controlled trial

A growing number of prenatal multivitamin (MVI) products use 5-methyltetrahydrofolate (5-MTHF) in place of the synthetic folic acid (FA), because FA needs to be reduced to 5-MTHF for use in cellular methylation reactions and excess FA consumption can increase unmetabolized FA (UMFA) concentrations i...

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Principais autores: Fulvia Draicchio, Jeanette Hausser, Mastaneh Sharafi, Adeline Grier-Welch, Arianne Vance, Nima Alamdari, Itamar D. Futterman, Scott Chudnoff, Olga Malysheva, Marie A. Caudill, Isabelle Hanson, Xinyin Jiang
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2026-03-01
Serier:Frontiers in Nutrition
Fag:
5-methyltetrahydrofolate
folic acid
pregnancy
prenatal multivitamin
unmetabolized folic acid
Online adgang:https://www.frontiersin.org/articles/10.3389/fnut.2026.1679067/full
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