Backtranslation of human RNA biosignatures of tuberculosis disease risk into the preclinical pipeline is condition dependent

ABSTRACT It is unclear whether human progression to active tuberculosis disease (TB) risk signatures are viable endpoint criteria for evaluations of treatments in development. TB is the deadliest infectious disease globally and more efficacious vaccines are needed to reduce this mortality. However,...

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Hauptverfasser:	Hannah Painter, Sasha E. Larsen, Brittany D. Williams, Hazem F. M. Abdelaal, Susan L. Baldwin, Helen A. Fletcher, Andrew Fiore-Gartland, Rhea N. Coler
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology 2025-01-01
Schriftenreihe:	mSphere
Schlagworte:	tuberculosis tuberculosis vaccines RNA risk signature correlate of risk preclinical drug studies
Online-Zugang:	https://journals.asm.org/doi/10.1128/msphere.00864-24
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