Backtranslation of human RNA biosignatures of tuberculosis disease risk into the preclinical pipeline is condition dependent

ABSTRACT It is unclear whether human progression to active tuberculosis disease (TB) risk signatures are viable endpoint criteria for evaluations of treatments in development. TB is the deadliest infectious disease globally and more efficacious vaccines are needed to reduce this mortality. However,...

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Principais autores:	Hannah Painter, Sasha E. Larsen, Brittany D. Williams, Hazem F. M. Abdelaal, Susan L. Baldwin, Helen A. Fletcher, Andrew Fiore-Gartland, Rhea N. Coler
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology 2025-01-01
coleção:	mSphere
Assuntos:	tuberculosis tuberculosis vaccines RNA risk signature correlate of risk preclinical drug studies
Acesso em linha:	https://journals.asm.org/doi/10.1128/msphere.00864-24
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