Structure-based design and characterization of Parkin-activating mutations

Parkin, an E3 ubiquitin ligase involved in Parkinson’s disease, is inactive in the basal state and is activated by PINK1 to mediate mitophagy. Here, we characterized 31 mutations and discovered three that activate Parkin and rescue loss of PINK1 phosphorylation. Autosomal recessive mutations in the...

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Principais autores:	Michael U Stevens, Nathalie Croteau, Mohamed A Eldeeb, Odetta Antico, Zhi Wei Zeng, Rachel Toth, Thomas M Durcan, Wolfdieter Springer, Edward A Fon, Miratul MK Muqit, Jean-François Trempe
Format:	Artigo
Jezik:	Inglês
Izdano:	Life Science Alliance LLC 2023-06-01
Serija:	Life Science Alliance
Online dostop:	https://www.life-science-alliance.org/lookup/doi/10.26508/lsa.202201419
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