Structure-based design and characterization of Parkin-activating mutations

Parkin, an E3 ubiquitin ligase involved in Parkinson’s disease, is inactive in the basal state and is activated by PINK1 to mediate mitophagy. Here, we characterized 31 mutations and discovered three that activate Parkin and rescue loss of PINK1 phosphorylation. Autosomal recessive mutations in the...

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Autori principali:	Michael U Stevens, Nathalie Croteau, Mohamed A Eldeeb, Odetta Antico, Zhi Wei Zeng, Rachel Toth, Thomas M Durcan, Wolfdieter Springer, Edward A Fon, Miratul MK Muqit, Jean-François Trempe
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Life Science Alliance LLC 2023-06-01
Serie:	Life Science Alliance
Accesso online:	https://www.life-science-alliance.org/lookup/doi/10.26508/lsa.202201419
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