Hematological phenotypes in GATA2 deficiency syndrome arise from aging, maladaptation to proliferation, and somatic events

Abstract: The GATA2 transcription factor is a pivotal regulator of hematopoiesis. Disruptions in the GATA2 gene drive severe hematologic abnormalities and are associated with an increased risk of myelodysplastic syndromes and acute myeloid leukemia; however, the mechanisms underlying the pathophysio...

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Váldodahkkit:	Juncal Fernandez-Orth, Cansu Koyunlar, Julia M. Weiss, Emanuele Gioacchino, Hans de Looper, Geoffroy Andrieux, Mariëtte ter Borg, Joke Zink, Irene Gonzalez-Menendez, Remco Hoogenboezem, Baris Yigit, Kirsten J. Gussinklo, Roger Mulet-Lazaro, Charlotte Wantzen, Sophie Pfeiffer, Christian Molnar, Eric Bindels, Sheila Bohler, Mathijs Sanders, Leticia Quintanilla-Martinez, Marcin Wlodarski, Melanie Boerries, Ivo P. Touw, Charlotte Niemeyer, Miriam Erlacher, Emma de Pater
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	Elsevier 2025-06-01
Ráidu:	Blood Advances
Liŋkkat:	http://www.sciencedirect.com/science/article/pii/S2473952925001892
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