Species- and strain-specific microbial modulation of interferon, innate immunity, and epithelial barrier in 2D air–liquid interface respiratory epithelial cultures

Abstract Background The microbiome regulates the respiratory epithelium’s immunomodulatory functions. To explore how the microbiome’s biodiversity affects microbe-epithelial interactions, we screened 58 phylogenetically diverse microbes for their transcriptomic effect on human primary bronchial air–...

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Bibliografiske detaljer

Principais autores:	Mian Horvath, Ruoyu Yang, Diana Cadena Castaneda, Megan Callender, Elizabeth S. Aiken, Anita Y. Voigt, Ryan Caldwell, José Fachi, Blanda Di Luccia, Zoe Scholar, Peter Yu, Andrew Salner, Marco Colonna, Karolina Palucka, Julia Oh
Format:	Artigo
Sprog:	Inglês
Udgivet:	BMC 2025-01-01
Serier:	BMC Biology
Fag:	Respiratory microbiome Bacteria Epithelium Interferon Antiviral immunity RNA-seq
Online adgang:	https://doi.org/10.1186/s12915-025-02129-7
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