Immune humanization of immunodeficient mice using diagnostic bone marrow aspirates from carcinoma patients.

Tumor xenografts in immunodeficient mice, while routinely used in cancer research, preclude studying interactions of immune and cancer cells or, if humanized by allogeneic immune cells, are of limited use for tumor-immunological questions. Here, we explore a novel way to generate cancer models with...

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Detalhes bibliográficos

Principais autores:	Melanie Werner-Klein, Judith Proske, Christian Werno, Katharina Schneider, Hans-Stefan Hofmann, Brigitte Rack, Stefan Buchholz, Roman Ganzer, Andreas Blana, Birgit Seelbach-Göbel, Ulrich Nitsche, Daniela N Männel, Christoph A Klein
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Public Library of Science (PLoS) 2014-01-01
Colecção:	PLoS ONE
Acesso em linha:	http://europepmc.org/articles/PMC4022674?pdf=render
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