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CNS myelination and remyelination depend on fatty acid synthesis by oligodendrocytes

Oligodendrocytes (OLs) support neurons and signal transmission in the central nervous system (CNS) by enwrapping axons with myelin, a lipid-rich membrane structure. We addressed the significance of fatty acid (FA) synthesis in OLs by depleting FA synthase (FASN) from OL progenitor cells (OPCs) in tr...

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Principais autores: Penelope Dimas, Laura Montani, Jorge A Pereira, Daniel Moreno, Martin Trötzmüller, Joanne Gerber, Clay F Semenkovich, Harald C Köfeler, Ueli Suter
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications Ltd 2019-05-01
Serier:eLife
Fag:
myelination
oligodendrocytes
remyelination
fatty acid synthesis
high fat diet
myelin lipids
Online adgang:https://elifesciences.org/articles/44702
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