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Neocryptomerin targets NAE1 to induce DNA re-replication and DNA damage by inhibiting neddylation-mediated CDT1 degradation in gastric cancer

Gastric cancer (GC) remains a globally prevalent malignancy, necessitating the development of effective therapeutics. Natural products are an important source for the development of anti-tumor drugs. Neocryptomerin (Neo) is a natural biflavonoid derived from Selaginella Herba, yet its efficacy and m...

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Principais autores: Peng Tan, Dongjun Fu, Fei Wang, Zhuguo Wang, Huiming Huang, Xuejiao Wei, Xinyu Qiu, Yufeng Gao, Ruoxin Zhang, Xiaoxue Wang, Wanying Xie, Zhongdong Hu
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2026-07-01
Serier:Pharmacological Research
Fag:
gastric cancer
Neocryptomerin
NAE1
neddylation
CDT1
DNA re-replication
Online adgang:http://www.sciencedirect.com/science/article/pii/S1043661826001702
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