Inhibition of Activated Coagulation Factor XII by the Phosphodiesterase-4 Inhibitor Roflumilast: In Vitro and In Silico Studies

Background: This study aimed to evaluate the effects of selected phosphodiesterase-4 inhibitors (PDE-4 inhibitors)—roflumilast, ibudilast, and crisaborole—on the activity of blood coagulation factor XII (FXII). In the intrinsic coagulation pathway, FXII is known to initiate the ka...

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Autors principals:	Hassan A. Madkhali, Mohd Nazam Ansari, Mubarak A. Alamri
Format:	Artigo
Idioma:	Inglês
Publicat:	IMR Press 2025-05-01
Col·lecció:	Frontiers in Bioscience-Landmark
Matèries:	blood coagulation factor xiia pde-4 inhibitors roflumilast in vitro in silico
Accés en línia:	https://www.imrpress.com/journal/FBL/30/5/10.31083/FBL38395
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