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Multimericity Amplifies the Synergy of BCR and TLR4 for B Cell Activation and Antibody Class Switching

Sustained signaling through the B cell antigen receptor (BCR) is thought to occur only when antigen(s) crosslink or disperse multiple BCR units, such as by multimeric antigens found on the surfaces of viruses or bacteria. B cell-intrinsic Toll-like receptor (TLR) signaling synergizes with the BCR to...

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Principais autores: Egest J. Pone, Jenny E. Hernandez-Davies, Sharon Jan, Emily Silzel, Philip L. Felgner, D. Huw Davies
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-05-01
Colecção:Frontiers in Immunology
Assuntos:
multimericity
B cells
class switching
B cell receptor (BCR)
Toll-like receptor (TLR)
synergy
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2022.882502/full
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