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Anti-inflammatory mechanisms and pharmacological actions of phycocyanobilin in a mouse model of experimental autoimmune encephalomyelitis: A therapeutic promise for multiple sclerosis

Cytokines, demyelination and neuroaxonal degeneration in the central nervous system are pivotal elements implicated in the pathogenesis of multiple sclerosis (MS) and its nonclinical model of experimental autoimmune encephalomyelitis (EAE). Phycocyanobilin (PCB), a chromophore of the biliprotein C-P...

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Principais autores: Javier Marín-Prida, Nancy Pavón-Fuentes, Nielsen Lagumersindez-Denis, Hanlet Camacho-Rodríguez, Ana Margarita García-Soca, Rocío de la Caridad Sarduy-Chávez, Érica Leandro Marciano Vieira, Juliana Carvalho-Tavares, Viviana Falcón-Cama, Julio Raúl Fernández-Massó, Ignacio Hernández-González, Gillian Martínez-Donato, Gerardo Guillén-Nieto, Eduardo Pentón-Arias, Mauro Martins Teixeira, Giselle Pentón-Rol
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-11-01
coleção:Frontiers in Immunology
Assuntos:
interferon-β
proinflammatory cytokines
remyelination
antioxidants
experimental autoimmune encephalomyelitis
multiple sclerosis
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1036200/full
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