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Path-based quantification of activation and repression in Boolean models using BooLEVARD

Abstract Boolean models are a powerful resource for studying dynamic processes of biological systems. However, their inherent discrete nature limits their ability to capture continuous aspects of signal transduction, such as signal strength or protein activation levels. Although existing tools provi...

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Bibliografische Detailangaben
Hauptverfasser: Marco Fariñas, Eirini Tsirvouli, John Zobolas, Tero Aittokallio, Åsmund Flobak, Kaisa Lehti
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Portfolio 2025-11-01
Schriftenreihe:npj Systems Biology and Applications
Online-Zugang:https://doi.org/10.1038/s41540-025-00605-y
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