The polarity protein Par3 regulates APP trafficking and processing through the endocytic adaptor protein Numb

The processing of amyloid precursor protein (APP) into β-amyloid peptide (Aβ) is a key step in the pathogenesis of Alzheimer’s disease (AD), and trafficking dysregulations of APP and its secretases contribute significantly to altered APP processing. Here we show that the cell polarity protein Par3 p...

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Prif Awduron:	Miao Sun, Suwaiba Z. Asghar, Huaye Zhang
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Elsevier 2016-09-01
Cyfres:	Neurobiology of Disease
Pynciau:	Cell polarity Trafficking Alzheimer disease Amyloid precursor protein (APP) Amyloid-β (Aβ) Par3
Mynediad Ar-lein:	http://www.sciencedirect.com/science/article/pii/S0969996116300687
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